With thiazide diuretics
Combined use can increase hypercalcemia risk, particularly with high-dose vitamin D or impaired kidney function.
Interaction evidence sourceVitamin / bone health
Prepared by the ezGLP team. Sources last checked .
Also known as Cholecalciferol, Vitamin D3, Ergocalciferol, Vitamin D2
Routes represented in the knowledgebase: Oral.
Supplement and prescription forms exist; excessive intake can cause hypercalcemia, kidney injury, soft-tissue calcification, and arrhythmias.
No validated PubMed or DOI link is currently curated for this entry.
Serious or important: hypercalcemia, kidney stones or failure, soft-tissue calcification, arrhythmia.
These effects are associated with excessive exposure.
Safety evidence sourceThese are general, pairwise evidence notes. Green identifies the potential-synergy category, while Lv3/Lv2/Lv1 communicates evidence strength; it does not guarantee benefit or cancel a safety warning.
Combined use can increase hypercalcemia risk, particularly with high-dose vitamin D or impaired kidney function.
Interaction evidence sourceA randomized human trial found magnesium plus vitamin D increased serum vitamin D status more than vitamin D alone.
Interaction evidence sourceRelated trial analysisNIH magnesium overviewSummarised from published literature for reference only, with citations to the source. Evidence is graded as reported and is not a recommendation to combine, dose, or use any compound.
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