Prescription metabolic / longevity

Metformin

Prepared by the ezGLP team. Sources last checked September 5, 2026.

Routes represented in the knowledgebase: Oral.

Educational overview

FDA-approved for type 2 diabetes; longevity use in healthy people is off-label and unproven. The label includes a lactic-acidosis boxed warning.

Category: Prescription metabolic / longevity
Routes represented: Oral
Storage context: Follow the product or pharmacy label; requirements vary by route and formulation.

Authoritative overview

Published literature

No validated PubMed or DOI link is currently curated for this entry.

Safety evidence

Common or reported: diarrhea, nausea, vomiting, gas, abdominal discomfort, headache.

Serious or important: lactic acidosis, vitamin B12 deficiency.

Safety evidence source

Interaction evidence

These are general, pairwise evidence notes. Green identifies the potential-synergy category, while Lv3/Lv2/Lv1 communicates evidence strength; it does not guarantee benefit or cancel a safety warning.

With carbonic anhydrase inhibitors

Safety flag

Additive metabolic acidosis can increase metformin-associated lactic-acidosis risk.

Interaction evidence source

With OCT2/MATE inhibitors

Safety flag

Reduced renal metformin clearance can increase exposure and lactic-acidosis risk.

Interaction evidence source

With alcohol

Safety flag

Alcohol potentiates metformin's effect on lactate metabolism and increases lactic-acidosis risk.

Interaction evidence source

With Cyanocobalamin

Safety flag

Long-term metformin use can reduce vitamin B12 absorption and serum B12 concentration.

Interaction evidence source

With Semaglutide

Complementary evidenceLv3

Semaglutide, tirzepatide, and liraglutide have been studied as add-on therapy to stable metformin, with complementary glucose and weight effects in type 2 diabetes.

Interaction evidence sourceTirzepatide trialLiraglutide trial

Summarised from published literature for reference only, with citations to the source. Evidence is graded as reported and is not a recommendation to combine, dose, or use any compound.

For personal tracking and education only. Not medical advice, diagnosis, or treatment, and not a medical device. Peptides may be prescription-only or unapproved where you live — consult a licensed healthcare professional.