With levothyroxine
Oral iron reduces levothyroxine absorption and can reduce treatment effectiveness.
Interaction evidence sourceMineral / hematologic
Prepared by the ezGLP team. Sources last checked .
Also known as Ferrous sulfate, Ferrous gluconate, Ferrous fumarate
Routes represented in the knowledgebase: Oral.
Confirm deficiency and formulation. Oral overdose can be fatal in children, while IV products carry hypersensitivity and hypotension risks.
No validated PubMed or DOI link is currently curated for this entry.
Common or reported: constipation, nausea, abdominal pain, vomiting, diarrhea.
Serious or important: intestinal injury, shock, organ failure, and death in overdose, especially in children.
Safety evidence sourceThese are general, pairwise evidence notes. Green identifies the potential-synergy category, while Lv3/Lv2/Lv1 communicates evidence strength; it does not guarantee benefit or cancel a safety warning.
Oral iron reduces levothyroxine absorption and can reduce treatment effectiveness.
Interaction evidence sourceIron doses of 25 mg or more taken at the same time can reduce zinc absorption.
Interaction evidence sourceVitamin C can increase the absorption and bioavailability of nonheme iron.
Interaction evidence sourceSummarised from published literature for reference only, with citations to the source. Evidence is graded as reported and is not a recommendation to combine, dose, or use any compound.
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