With methotrexate used for cancer
Safety flag
Supplemental folate can interfere with antifolate cancer therapy.
Interaction evidence source All research profiles
Vitamin
Folic acid
Prepared by the ezGLP team. Sources last checked .
Also known as Vitamin B9, Folate
Routes represented in the knowledgebase: Oral / Subcutaneous (SubQ).
Educational overview
Supplement and prescription replacement; high intake can mask anemia while neurologic injury from B12 deficiency continues.
- Category
- Vitamin
- Routes represented
- Oral / Subcutaneous (SubQ)
- Storage context
- Follow the product or pharmacy label; requirements vary by route and formulation.
Published literature
No validated PubMed or DOI link is currently curated for this entry.
Safety evidence
Serious or important: masking of B12-related anemia while neurologic injury continues.
Safety evidence sourceInteraction evidence
These are general, pairwise evidence notes. Green identifies the potential-synergy category, while Lv3/Lv2/Lv1 communicates evidence strength; it does not guarantee benefit or cancel a safety warning.
With cyanocobalamin (vitamin B12)
Complementary evidenceLv3
A randomized human trial found folic acid plus vitamin B12 lowered homocysteine more than folic acid alone.
Interaction evidence sourceCardiovascular outcome trialCardiovascular outcome trialSummarised from published literature for reference only, with citations to the source. Evidence is graded as reported and is not a recommendation to combine, dose, or use any compound.
For personal tracking and education only. Not medical advice, diagnosis, or treatment, and not a medical device. Peptides may be prescription-only or unapproved where you live — consult a licensed healthcare professional.